At the time, the idea that newly isolated human genes of unknown function could prove useful for drug development was widely criticized.
Haseltine authored several articles that laid out the fundamental structure of the new discipline.
Genetic Structure and Regulation of HIV-1 (EA.).
132 The laboratory also created hybrid viruses that carry some monkey and some HIV genes-the so-called shiv viruses-so that new drugs and vaccines could be developed using primate heiße lokale sex Termine models.Pedersen, FS; Crowther RL; Hays EF; Nowinski RC; Haseltine WA (1982).Antoni; Whitehorn, Erik.; Baumeister, Kirk; Ivanoff, Lucinda; Petteway, Stephen.; Pearson, Mark.; Lautenberger, James.; Papas, Takis.; Ghrayeb, John; Chang, Nancy.; Gallo, Robert.; Wong-Staal, Flossie (1985).The Emergence of Tissue Engineering as a Research Field."Use of ExonucleaseIII to Determine the Site of Stable Lesions in Defined Sequences of DNA; The Cyclobutane Pyrimidine Dimer and cis and trans Dichloradiammine Platinum II Examples".In fact work with the HIV genome was perhaps the first time primary knowledge of a new organism originated from studies of the genome.Zazopoulos, E; Haseltine WA (1992).15 Cancer Research edit In 1976, he joined the faculty of the new comprehensive cancer center, the Dana Farber Cancer Institute affiliated with Harvard Medical School.He predicted that drugs that target these proteins will putzfrau gesucht berlin also be effective in treating the infection.Annals of Emergency Medicine.
Cohen, J (October 2001).
American Association for the Advancement of Science : 385400.
Improving the Health of Mother and Child: Solutions from India.A Rational Approach To Chemotherapy of aids.His laboratory discovered that the key determinant of the ability of retroviruses, those that do not carry oncogenes, to cause cancer is their ability to rapidly replicate in cells that themselves grow rapidly."Biological and Biochemical Characterization of an SV40 Transformed Xeroderma Pigmentosum Cell Line".Haseltine devoted part of his laboratory to the study retroviruses in these animals in the hopes that they would provide insight into human disease."Relationship of Retroviruses Isolated from Leukemia Tissues to the Woolly-Monkey-Gibbon Ape Leukemia Viruses".
"Replication and Pathogenesis of HIV-1 Retrovirus Relevant to Drug Design.
"Trans-activation of the Bovine Leukemia Virus Long Terminal Repeat".